@article {Haast2020.02.13.947382,
author = {Haast, Roy A.M. and Lau, Jonathan C. and Ivanov, Dimo and Menon, Ravi S. and Uludag, Kamil and Khan, Ali R.},
title = {Effects of MP2RAGE B1+ sensitivity on inter-site T1 reproducibility and morphometry at 7T},
month = {feb},
year = {2020},
doi = {10.1101/2020.02.13.947382},
publisher = {Cold Spring Harbor Laboratory},
URL = {https://www.biorxiv.org/content/early/2020/02/14/2020.02.13.947382},
eprint = {https://www.biorxiv.org/content/early/2020/02/14/2020.02.13.947382.full.pdf},
journal = {bioRxiv}
}
@inproceedings{Haast2019d,
address = {Arnhem, Netherlands},
author = {Haast, Roy A.M. and Kashyap, Sriranga and DeKraker, Jordan and Ivanov, Dimo and Poser, Benedikt A. and Khan, Ali R.},
booktitle = {12th annual meeting of the ISMRM Benelux chapter},
pages = {xx},
title = {{Disentangling hippocampal perfusion from the macrovasculature using ASL and TOF at 7T}},
month = {jan},
year = {2020}
}
@inproceedings{Haast2019c,
address = {Minneapolis, Minnesota, USA},
author = {Haast, Roy A.M. and Lau, Jonathan C. and Ivanov, Dimo and Uludag, Kamil and Khan, Ali R.},
booktitle = {Minnesota Workshop on High and Ultra-high Field Imaging},
pages = {xx},
title = {{MP2RAGE B1+ correction revisited: inter-site comparison & subcortical morphometry}},
month = {nov},
year = {2019}
}
@article{Kneppers2019,
author = {Kneppers, Anita E.M. and Haast, Roy A.M. and Langen, Ramon C.J. and Verdijk, Lex B. and Leermakers, Pieter A. and Gosker, Harry R. and van Loon, Luc J.C. and Lainscak, Mitja and Schols, Annemie M.W.J.},
doi = {10.1002/jcsm.12370},
issn = {21905991},
journal = {Journal of Cachexia, Sarcopenia and Muscle},
keywords = {Chronic obstructive pulmonary disease,Cluster analysis,Exercise training,Muscle plasticity,Peripheral muscle dysfunction},
month = {jan},
publisher = {Springer Nature},
title = {{Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis}},
url = {http://doi.wiley.com/10.1002/jcsm.12370},
year = {2019}
}
@article{Valles2011,
abstract = {Because of its anatomical organization, the rodent whisker-to-barrel system is an ideal model to study experience-dependent plasticity. Manipulation of sensory input causes changes in the properties of the barrels at the physiological, structural, and functional levels. However, much less is known about the molecular events underlying these changes. To explore such molecular events, we have used a genomewide approach to identify key genes and molecular pathways involved in experience-induced plasticity in the barrel cortex of adult rats. Given the natural tendency of rats to explore novel objects, exposure to an enriched environment (EE) was used to stimulate the activity of the whisker-to-barrel cortex in vivo. Microarray analysis at two different time points after EE revealed differential expression of genes encoding transcription factors, including nuclear receptors, as well as of genes involved in the regulation of synaptic plasticity, cell differentiation, metabolism, and, surprisingly, blood vessel morphogenesis. These expression differences reflect changes in somatosensory information processing because unilateral whisker clipping showed EE-induced differential expression patterns in the spared versus deprived barrel cortex. Finally, in situ hybridization revealed cortical layer patterns specific for each selected gene. Together, the present study offers the first genomewide exploration of the key genes regulated by somatosensory stimulation in the barrel cortex and thus provides a solid experimental framework for future in-depth analysis of the mechanisms underlying experience-dependent plasticity.},
author = {Valles, Astrid and Boender, Arjen J and Gijsbers, Steef and Haast, Roy A. M. and Martens, Gerard J. M. and de Weerd, Peter},
doi = {10.1523/JNEUROSCI.6514-10.2011},
journal = {The Journal of Neuroscience},
month = {apr},
number = {16},
pages = {6140 LP -- 6158},
title = {{Genomewide Analysis of Rat Barrel Cortex Reveals Time- and Layer-Specific mRNA Expression Changes Related to Experience-Dependent Plasticity}},
url = {http://www.jneurosci.org/content/31/16/6140.abstract},
volume = {31},
year = {2011}
}
@article{Haast2012,
abstract = {Sex differences in stroke are observed across epidemiologic studies, pathophysiology, treatments, and outcomes. These sex differences have profound implications for effective prevention and treatment and are the focus of this review. Epidemiologic studies reveal a clear age-by-sex interaction in stroke prevalence, incidence, and mortality. While premenopausal women experience fewer strokes than men of comparable age, stroke rates increase among postmenopausal women compared with age-matched men. This postmenopausal phenomenon, in combination with living longer, are reasons for women being older at stroke onset and suffering more severe strokes. Thus, a primary focus of stroke prevention has been based on sex steroid hormone-dependent mechanisms. Sex hormones affect different (patho)physiologic functions of the cerebral circulation. Clarifying the impact of sex hormones on cerebral vasculature using suitable animal models is essential to elucidate male–female differences in stroke pathophysiology and devel...},
author = {Haast, Roy A.M. and Gustafson, Deborah R and Kiliaan, Amanda J},
doi = {10.1038/jcbfm.2012.141},
issn = {0271-678X},
journal = {Journal of Cerebral Blood Flow {\&} Metabolism},
keywords = {epidemiology,gender,pathophysiology,risk factors,steroids,stroke},
month = {dec},
number = {12},
pages = {2100--2107},
publisher = {SAGE PublicationsSage UK: London, England},
title = {{Sex Differences in Stroke}},
url = {http://journals.sagepub.com/doi/10.1038/jcbfm.2012.141},
volume = {32},
year = {2012}
}
@article{Wilbers2014a,
abstract = {BACKGROUND AND PURPOSE Carotid artery vasculopathy is a long-term complication of radiotherapy (RT) of the neck. We investigated the change in carotid intima media thickness (IMT) and the incidence of ischemic stroke in the first 7years after radiotherapy (RT) of the neck. MATERIALS AND METHODS A multicentre prospective cohort study among patients treated for Head and Neck Cancer (HNC) assessed carotid IMT at baseline (before RT) and after a median of 7years follow-up. We also screened for cerebrovascular risk factors and events. RESULTS 48 patients underwent IMT measurement at baseline and follow-up (median age 61years, range 29–87). Mean IMT of the irradiated common carotid arteries was 0.64mm at baseline and 0.74mm at follow-up (p=0.002). Mean delta IMT in the irradiated and non-irradiated common carotid arteries were 0.11 and 0.02mm (p=0.03). Incidence rate of stroke in our cohort, compared to the Dutch population was 8.9 versus 1.5 per 1.000 person years. CONCLUSIONS IMT in irradiated carotid arteries was significantly increased in the first 7years after RT. The incidence rate of stroke was six fold increased. Patients treated with RT for HNC have sustained risk for developing atherosclerosis of the carotid arteries and future stroke.},
author = {Wilbers, Joyce and Dorresteijn, Lucille D. and Haast, Roy A.M. and Hoebers, Frank J. and Kaanders, Johannes H. and Boogerd, Willem and van Werkhoven, Erik D. and Nowee, Marlies E. and Hansen, Hendrik H.G. and de Korte, Chris L. and Kappelle, Arnoud C. and van Dijk, Ewoud J.},
doi = {10.1016/J.RADONC.2014.10.012},
file = {:home/ROBARTS/rhaast/.local/share/data/Mendeley Ltd./Mendeley Desktop/Downloaded/Wilbers et al. - 2014 - Progression of carotid intima media thickness after radiotherapy A long-term prospective cohort study.pdf:pdf},
issn = {0167-8140},
journal = {Radiotherapy and Oncology},
month = {dec},
number = {3},
pages = {359--363},
publisher = {Elsevier},
title = {{Progression of carotid intima media thickness after radiotherapy: A long-term prospective cohort study}},
url = {https://www.sciencedirect.com/science/article/pii/S0167814014004241?via{\%}3Dihub},
volume = {113},
year = {2014}
}
@article{Wilbers2014,
abstract = {Successful treatment options for cancer result in more young long-term survivors prone for long-term complications. Carotid artery vasculopathy is a potential long-term complication after radiotherapy of the neck, resulting in cerebrovascular events and probably deficits in cognitive and motor functioning. Better insight into the underlying pathofysiology of radiotherapy induced carotid artery vasculopathy is needed for prognostic purposes and to develop preventive strategies. The current study is a prospective cohort study on the long-term cerebral and vascular complications after radiotherapy of the neck, in 103 patients treated for head and neck cancer, included in our study database between 2002 and 2008. Baseline protocol (before radiotherapy) included screening for cerebrovascular risk factors and intima media thickness measurement of carotid arteries by ultrasonography. Follow-up assessment more than 5 years after radiotherapy included screening of cerebrovascular risk factors, cerebrovascular events, neurological examination with gait and balance tests, extensive neuropsychological examination, self-report questionnaires, ultrasonography of the carotid arteries with measurement of intima media thickness and elastography, magnetic resonance imaging of the brain and magnetic resonance angiography of the carotid arteries. The current study adds to the understanding of the causes and consequences of long-term cerebral and vascular changes after radiotherapy of the neck. These data will be helpful to develop a protocol for diagnostic and preventive strategies for long-term neurological complications in future head and neck cancer patients with anticipated radiotherapy treatment.},
author = {Wilbers, Joyce and Kappelle, Arnoud C and Kessels, Roy PC and Steens, Stefan CA and Meijer, Frederick JA and Kaanders, Johannes H and Haast, Roy A.M. and Versteeg, Laura E and Tuladhar, Anil M and de Korte, Chris L and Hansen, Hendrik HG and Hoebers, Frank J and Boogerd, Willem and van Werkhoven, Erik D and Nowee, Marlies E and Hart, Guus and Bartelink, Harry and Dorresteijn, Lucille D and van Dijk, Ewoud J},
doi = {10.1186/1471-2377-14-132},
file = {:home/ROBARTS/rhaast/.local/share/data/Mendeley Ltd./Mendeley Desktop/Downloaded/Wilbers et al. - 2014 - Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients a p.pdf:pdf},
issn = {1471-2377},
journal = {BMC Neurology},
keywords = {Neurochemistry,Neurology,Neurosurgery},
month = {dec},
number = {1},
pages = {132},
publisher = {BioMed Central},
title = {{Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol}},
url = {http://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-14-132},
volume = {14},
year = {2014}
}
@inproceedings{Haast2015a,
address = {Ghent, Belgium},
author = {Haast, Roy A.M. and Ivanov, Dimo and Formisano, Elia and Uludag, Kamil},
booktitle = {Proceedings of the annual meeting of ISMRM Benelux chapter},
pages = {xx},
title = {{Comparing different contrasts for myelin-related cortical mapping at 7 Tesla}},
year = {2015}
}
@inproceedings{Haast2015,
address = {Toronto, ON, Canada},
author = {Haast, Roy A.M. and Ivanov, Dimo and Formisano, Elia and Uludag, Kamil},
booktitle = {Proceedings of the 23rd annual meeting of International Society for Magnetic Resonance in Medicine},
pages = {xx},
title = {{Comparing different contrasts for myelin-related cortical mapping at 7 Tesla}},
year = {2015}
}
@article{Haast2015,
abstract = {The use of dietary intervention has evolved into a promising approach to prevent the onset and progression of brain diseases. The positive relationship between intake of omega-3 long chain polyunsaturated fatty acids ($\omega$3-LCPUFAs) and decreased onset of disease- and aging-related deterioration of brain health is increasingly endorsed across epidemiological and diet-interventional studies. Promising results are found regarding to the protection of proper brain circulation, structure and functionality in healthy and diseased humans and animal models. These include enhanced cerebral blood flow (CBF), white and gray matter integrity, and improved cognitive functioning, and are possibly mediated through increased neurovascular coupling, neuroprotection and neuronal plasticity, respectively. Contrary, studies investigating diets high in saturated fats provide opposite results, which may eventually lead to irreversible damage. Studies like these are of great importance given the high incidence of obesity caused by the increased and decreased consumption of respectively saturated fats and $\omega$3-LCPUFAs in the Western civilization. This paper will review in vivo research conducted on the effects of $\omega$3-LCPUFAs and saturated fatty acids on integrity (circulation, structure and function) of the young, aging and diseased brain.},
author = {Haast, Roy A.M. and Kiliaan, Amanda J.},
doi = {10.1016/J.PLEFA.2014.01.002},
file = {:home/ROBARTS/rhaast/.local/share/data/Mendeley Ltd./Mendeley Desktop/Downloaded/Haast, Kiliaan - 2015 - Impact of fatty acids on brain circulation, structure and function.pdf:pdf},
issn = {0952-3278},
journal = {Prostaglandins, Leukotrienes and Essential Fatty Acids},
month = {jan},
pages = {3--14},
publisher = {Churchill Livingstone},
title = {{Impact of fatty acids on brain circulation, structure and function}},
url = {https://www.sciencedirect.com/science/article/pii/S0952327814000052?via{\%}3Dihub},
volume = {92},
year = {2015}
}
@inproceedings{Haast2016,
address = {Geneva, Switzerland},
author = {Haast, Roy A.M. and Dimo, Ivanov and Formisano, Elia and Uludag, Kamil},
booktitle = {Organization of Human Brain Mapping},
title = {{Multi-Parameter Quantitative Brain Anatomy at 7 Tesla}},
year = {2016},
pages = {xx}
}
@inproceedings{Haast2016a,
address = {Heidelberg, Germany},
author = {Haast, Roy A.M. and Ivanov, Dimo and Jansen, Jacobus F.A. and Smeets, Hubert J. and de Coo, Irenaeus F.M. and Formisano, Elia and Uludag, Kamil},
booktitle = {Proceedings of the Ultra High Field MRI: Technological Advances {\&} Clinical Applications workshop},
pages = {xx},
title = {{Quantitative brain imaging in MELAS patients}},
year = {2016}
}
@article{Wiesmann2016,
abstract = {APOE $\epsilon$ 4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer's disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD. We hypothesize that the diet could inhibit AD-like pathologies in apoE4 mice, specifically cerebrovascular and connectivity impairment. Moreover, we evaluated the diet effect on cerebral blood flow (CBF), functional connectivity (FC), gray/white matter integrity, and postsynaptic density in aging apoE4 mice. At 10–12 months, apoE4 mice did not display prominent pathological differences compared to wild-type (WT) mice. However, 16–18-month-old apoE4 mice revealed reduced CBF and accelerated synaptic loss. The diet increased cortical CBF and amount of synapses and improved white matter integrity and FC in both aging apoE4 and WT mice. We demonstrated that protective mechanisms on vascular and synapse health are enhanced by Fortasyn, independent of apoE genotype. We further showed the efficacy of a multimodal translational approach, including advanced MR neuroimaging, to study dietary intervention on brain structure and function in aging.},
author = {Wiesmann, Maximilian and Zerbi, Valerio and Jansen, Diane and Haast, Roy A.M. and Lutjohann, Dieter and Broersen, Laus M. and Heerschap, Arend and Kiliaan, Amanda J.},
doi = {10.1155/2016/6846721},
issn = {2090-5904},
journal = {Neural Plasticity},
month = {mar},
pages = {1--15},
publisher = {Hindawi},
title = {{A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice}},
url = {http://www.hindawi.com/journals/np/2016/6846721/},
volume = {2016},
year = {2016}
}
@article{Haast2016,
abstract = {Different magnetic resonance (MR) parameters, such as R1 (= 1/T1) or T2*, have been used to visualize non-invasively the myelin distribution across the cortical sheet. Myelin contrast is consistently enhanced in the primary sensory and some higher order cortical areas (such as MT or the cingulate cortex), which renders it suitable for subject-specific anatomical cortical parcellation. However, no systematic comparison has been performed between the previously proposed MR parameters, i.e. the longitudinal and transversal relaxation values (or their ratios), for myelin mapping at 7 Tesla. In addition, usually these MR parameters are acquired in a non-quantitative manner (“weighted” parameters). Here, we evaluated the differences in ‘parcellability', contrast-to-noise ratio (CNR) and inter- and intra-subject variability and reproducibility, respectively, between high-resolution cortical surface maps based on these weighted MR parameters and their quantitative counterparts in ten healthy subjects. All parameters were obtained in a similar acquisition time and possible transmit- or receive-biases were removed during post-processing. It was found that CNR per unit time and parcellability were lower for the transversal compared to the longitudinal relaxation parameters. Further, quantitative R1 was characterized by the lowest inter- and intra-subject coefficient of variation (5.53{\%} and 1.63{\%}, respectively), making R1 a better parameter to map the myelin distribution compared to the other parameters. Moreover, quantitative MRI approaches offer the advantage of absolute rather than relative characterization of the underlying biochemical composition of the tissue, allowing more reliable comparison within subjects and between healthy subjects and patients. Finally, we explored two parcellation methods (thresholding the MR parameter values vs. surface gradients of these values) to determine areal borders based on the cortical surface pattern. It is shown that both methods are partially observer-dependent, needing manual interaction (i.e. choice of threshold or connecting high gradient values) to provide unambiguous borders.},
author = {Haast, Roy A. M. and Ivanov, Dimo and Formisano, Elia and Uludag, Kamil},
doi = {10.3389/fnana.2016.00112},
file = {:home/ROBARTS/rhaast/.local/share/data/Mendeley Ltd./Mendeley Desktop/Downloaded/Haast et al. - 2016 - Reproducibility and Reliability of Quantitative and Weighted T1 and T2∗ Mapping for Myelin-Based Cortical Par(2).pdf:pdf},
issn = {1662-5129},
journal = {Frontiers in Neuroanatomy},
keywords = {Anatomy,MR parameters,Ultra-high-field MRI,myelin-related cortical mapping,quantitative MRI},
month = {nov},
pages = {112},
publisher = {Frontiers},
title = {{Reproducibility and Reliability of Quantitative and Weighted T1 and T2* Mapping for Myelin-Based Cortical Parcellation at 7 Tesla}},
url = {http://journal.frontiersin.org/article/10.3389/fnana.2016.00112/full},
volume = {10},
year = {2016}
}
@inproceedings{Gardumi2017,
address = {Honolulu, HI, USA},
author = {Gardumi, Anna and Ivanov, Dimo and Haast, Roy A.M. and Pfeuffer, Josef and Poser, Benedikt A. and Uludag, Kamil},
booktitle = {Proceedings of the 25th annual meeting of International Society for Magnetic Resonance in Medicine},
pages = {xx},
title = {{Acquisition Parameters on CBF and BOLD Sensitivity in 3 and 7 Tesla ASL FMRI}},
year = {2017}
}
@inproceedings{Haast2017b,
address = {Honolulu, HI, USA},
author = {Haast, Roy A.M. and Ivanov, Dimo and Formisano, Elia and Uludag, Kamil},
booktitle = {Proceedings of the 25th annual meeting of International Society for Magnetic Resonance in Medicine},
pages = {xx},
title = {{Cerebral blood flow as a marker for cortical parcellation}},
year = {2017}
}
@inproceedings{Haast2017,
address = {Honolulu, HI, USA},
author = {Haast, Roy A.M. and Ivanov, Dimo and Jansen, Jacobus F.A. and Smeets, Hubert J.M. and de Coo, Irenaeus F.M. and Formisano, Elia and Uludag, Kamil},
booktitle = {Proceedings of the 25th annual meeting of International Society for Magnetic Resonance in Medicine},
pages = {xx},
title = {{Cortical Thickness in Relation to m.3243A{\textgreater}G Mutation Load in MELAS Syndrome}},
year = {2017}
}
@inproceedings{Haast2017a,
address = {Honolulu, HI, USA},
author = {Haast, Roy A.M. and Ivanov, Dimo and Formisano, Elia and Uludag, Kamil},
booktitle = {Proceedings of the 25th annual meeting of International Society for Magnetic Resonance in Medicine},
pages = {xx},
title = {{The Effects of B1+ Correction of MP2RAGE on Estimating Cortical Thickness and T1 at 7T}},
year = {2017}
}
@article{Ivanov2017,
abstract = {Arterial spin labeling (ASL) is the primary non-invasive MRI approach to measure baseline cerebral blood flow (CBF) in healthy subjects and patients. ASL also allows concurrent functional BOLD signal and CBF measurements, but the latter typically suffer from low contrast-to-noise (CNR) ratio. Ultra-high-field imaging significantly boosts BOLD signal CNR. However, it is contested whether also CBF CNR benefits from increasing magnetic field strength, especially given that technical challenges related to field inhomogeneities and power deposition constraints exist. Recently, we presented an optimized PASL technique that utilizes tr-FOCI inversion pulses and dielectric pads to overcome the temporal resolution limitations of previous 7T ASL implementations (Ivanov et al., in press; 2017). The primary goal of this study was to compare its performance to that of 3T ASL approaches – both pulsed ASL (PASL) and pseudo-continuous (pCASL) – concerning functional studies using simultaneous CBF and BOLD signal acquisition. To this aim, we investigated a wide range of parameters that can influence CBF and BOLD signal sensitivities: spatial resolution, labeling scheme, parallel imaging and echo time. We found that 7T ASL is superior in terms of CBF and BOLD temporal signal-to-noise ratio (SNR) and activation volume compared to all 3T ASL variants, in particular at high spatial resolution. Our results show that the advantages of 7T for ASL stem from increased image SNR, especially when parallel imaging is used. The gray matter baseline CBF was in good agreement for all 3T ASL variants, but a significantly lower value was obtained at 7T. The labeling scheme utilized was also found to significantly influence the measured perfusion territories CBF. In conclusion, a single-echo accelerated 7T PASL is recommended for high spatial and temporal resolution CBF and BOLD imaging, while a 3T dual-echo pCASL approach without parallel imaging may be preferred for low (i.e., 3mm isotropic and lower) resolution functional perfusion and BOLD applications.},
author = {Ivanov, Dimo and Gardumi, Anna and Haast, Roy A.M. and Pfeuffer, Josef and Poser, Benedikt A. and Uludag, Kamil},
doi = {10.1016/J.NEUROIMAGE.2017.05.038},
file = {:home/ROBARTS/rhaast/.local/share/data/Mendeley Ltd./Mendeley Desktop/Downloaded/Ivanov et al. - 2017 - Comparison of 3 T and 7 T ASL techniques for concurrent functional perfusion and BOLD studies.pdf:pdf},
issn = {1053-8119},
journal = {NeuroImage},
month = {aug},
pages = {363--376},
publisher = {Academic Press},
title = {{Comparison of 3T and 7T ASL techniques for concurrent functional perfusion and BOLD studies}},
url = {https://www.sciencedirect.com/science/article/pii/S1053811917304305?via{\%}3Dihub},
volume = {156},
year = {2017}
}
@inproceedings{Ivanov2018,
address = {Paris, France},
author = {Ivanov, Dimo and Kashyap, Sriranga and Haast, Roy A.M. and Janssens, Shanice C.E.W. and Smeets, Hubert J.M. and Huber, Laurentius and Poser, Benedikt A. and Uludag, Kamil},
booktitle = {Proceedings of the 26th annual meeting of International Society for Magnetic Resonance in Medicine},
pages = {xx},
title = {{Whole-brain sub-millimeter cerebral blood flow map using 7T ASL}},
year = {2018}
}
@inproceedings{Kneppers2018,
address = {Paris, France},
author = {Kneppers, Anita E.M. and Haast, Roy A.M. and Langen, Ramon C.J. and Verdijk, Lex and Leermakers, Pieter J. and Gosker, Harry and van Loon, Luc and Lainscak, Mitja and Schols, Annemie M.W.J.},
booktitle = {Proceedings of the annual meeting of European Respiratory Society},
pages = {xx},
title = {{Unbiased analysis of skeletal muscle molecular responses upon pulmonary rehabilitation in advanced COPD}},
year = {2018}
}
@inproceedings{Kneppers2018a,
address = {Rome, Italy,},
author = {Kneppers, Anita E.M. and Haast, Roy A.M. and Langen, Ramon C.J. and Verdijk, Lex and Leermakers, Pieter J. and Gosker, Harry and van Loon, Luc and Lainscak, Mitja and Schols, Annemie M.W.J.},
booktitle = {Abstracts of the 11th International Conference on Cachexia, Sarcopenia and Muscle Wasting},
doi = {10.1002/jcsm.12284},
file = {:home/ROBARTS/rhaast/.local/share/data/Mendeley Ltd./Mendeley Desktop/Downloaded/Unknown - 2018 - Abstracts of the 11 supthsup International Conference on Cachexia, Sarcopenia and Muscle Wasting, Maastricht, The Nethe.pdf:pdf},
isbn = {9786050105049},
issn = {21905991},
month = {dec},
number = {1},
pages = {1121 -- 1184},
publisher = {Springer Nature},
title = {{Distinct skeletal muscle molecular responses to pulmonary rehabilitation in COPD: a cluster analysis}},
url = {https://onlinelibrary.wiley.com/doi/10.1002/jcsm.12365},
volume = {9},
year = {2018}
}
@article{Haast2018a,
author = {Haast, Roy A.M. and Ivanov, Dimo and Uludag, Kamil},
doi = {10.1002/hbm.24011},
file = {:home/ROBARTS/rhaast/.local/share/data/Mendeley Ltd./Mendeley Desktop/Downloaded/Haast, Ivanov, Uludağ - 2018 - The impact of B1 correction on MP2RAGE cortical T sub1sub and apparent cortical thickness at 7T.pdf:pdf},
issn = {10659471},
journal = {Human Brain Mapping},
keywords = {7T MRI,MP2RAGE,cortical thickness,quantitative T1,transmit bias field},
month = {jun},
number = {6},
pages = {2412--2425},
publisher = {Wiley-Blackwell},
title = {{The impact of B1+ correction on MP2RAGE cortical T1 and apparent cortical thickness at 7T}},
url = {http://doi.wiley.com/10.1002/hbm.24011},
volume = {39},
year = {2018}
}
@article{Haast2018b,
abstract = {One of the most common mitochondrial DNA (mtDNA) mutations, the A to G transition at base pair 3243, has been linked to changes in the brain, in addition to commonly observed hearing problems, diabetes and myopathy. However, a detailed quantitative description of m.3243A{\textgreater}G patients' brains has not been provided so far. In this study, ultra-high field MRI at 7T and volume- and surface-based data analyses approaches were used to highlight morphology (i.e. atrophy)-, microstructure (i.e. myelin and iron concentration)- and metabolism (i.e. cerebral blood flow)-related differences between patients (N = 22) and healthy controls (N = 15). The use of quantitative MRI at 7T allowed us to detect subtle changes of biophysical processes in the brain with high accuracy and sensitivity, in addition to typically assessed lesions and atrophy. Furthermore, the effect of m.3243A{\textgreater}G mutation load in blood and urine epithelial cells on these MRI measures was assessed within the patient population and revealed that blood levels were most indicative of the brain's state and disease severity, based on MRI as well as on neuropsychological data. Morphometry MRI data showed a wide-spread reduction of cortical, subcortical and cerebellar gray matter volume, in addition to significantly enlarged ventricles. Moreover, surface-based analyses revealed brain area-specific changes in cortical thickness (e.g. of the auditory cortex), and in T1, T2* and cerebral blood flow as a function of mutation load, which can be linked to typically m.3243A{\textgreater}G-related clinical symptoms (e.g. hearing impairment). In addition, several regions linked to attentional control (e.g. middle frontal gyrus), the sensorimotor network (e.g. banks of central sulcus) and the default mode network (e.g. precuneus) were characterized by alterations in cortical thickness, T1, T2* and/or cerebral blood flow, which has not been described in previous MRI studies. Finally, several hypotheses, based either on vascular, metabolic or astroglial implications of the m.3243A{\textgreater}G mutation, are discussed that potentially explain the underlying pathobiology. To conclude, this is the first 7T and also the largest MRI study on this patient population that provides macroscopic brain correlates of the m.3243A{\textgreater}G mutation indicating potential MRI biomarkers of mitochondrial diseases and might guide future (longitudinal) studies to extensively track neuropathological and clinical changes.},
author = {Haast, Roy A.M. and Ivanov, Dimo and IJsselstein, Rutger J.T. and Sallevelt, Suzanne C.E.H. and Jansen, Jacobus F.A. and Smeets, Hubert J.M. and de Coo, Irenaeus F.M. and Formisano, Elia and Uludag, Kamil},
doi = {10.1016/J.NICL.2018.01.017},
file = {:home/ROBARTS/rhaast/.local/share/data/Mendeley Ltd./Mendeley Desktop/Downloaded/Haast et al. - 2018 - Anatomic {\&}amp metabolic brain markers of the m.3243A{\&}gtG mutation A multi-parametric 7T MRI study.pdf:pdf},
issn = {2213-1582},
journal = {NeuroImage: Clinical},
month = {jan},
pages = {231--244},
publisher = {Elsevier},
title = {{Anatomic {\&} metabolic brain markers of the m.3243A{\textgreater}G mutation: A multi-parametric 7T MRI study}},
url = {https://www.sciencedirect.com/science/article/pii/S2213158218300172?via{\%}3Dihub},
volume = {18},
year = {2018}
}
@article{Gulban2018,
abstract = {High-resolution (functional) magnetic resonance imaging (MRI) at ultra high magnetic fields (7 Tesla and above) enables researchers to study how anatomical and functional properties change within the cortical ribbon, along surfaces and across cortical depths. These studies require an accurate delineation of the gray matter ribbon, which often suffers from inclusion of blood vessels, dura mater and other non-brain tissue. Residual segmentation errors are commonly corrected by browsing the data slice-by-slice and manually changing labels. This task becomes increasingly laborious and prone to error at higher resolutions since both work and error scale with the number of voxels. Here we show that many mislabeled, non-brain voxels can be corrected more efficiently and semi-automatically by representing three-dimensional anatomical images using two-dimensional histograms. We propose both a uni-modal (based on first spatial derivative) and multi-modal (based on compositional data analysis) approach to this representation and quantify the benefits in 7 Tesla MRI data of nine volunteers. We present an openly accessible Python implementation of these approaches and demonstrate that editing cortical segmentations using two-dimensional histogram representations as an additional post-processing step aids existing algorithms and yields improved gray matter borders. By making our data and corresponding expert (ground truth) segmentations openly available, we facilitate future efforts to develop and test segmentation algorithms on this challenging type of data.},
author = {Gulban, Omer Faruk and Schneider, Marian and Marquardt, Ingo and Haast, Roy A. M. and {De Martino}, Federico},
doi = {10.1371/journal.pone.0198335},
editor = {Pham, Dzung},
file = {:home/ROBARTS/rhaast/.local/share/data/Mendeley Ltd./Mendeley Desktop/Downloaded/Gulban et al. - 2018 - A scalable method to improve gray matter segmentation at ultra high field MRI.pdf:pdf},
issn = {1932-6203},
journal = {PLOS ONE},
month = {jun},
number = {6},
pages = {e0198335},
publisher = {Public Library of Science},
title = {{A scalable method to improve gray matter segmentation at ultra high field MRI}},
url = {http://dx.plos.org/10.1371/journal.pone.0198335},
volume = {13},
year = {2018}
}
@inproceedings{Haast2019,
address = {Rome, Italy},
author = {Haast, Roy A.M. and Valente, Giancarlo and Uludag, Kamil},
booktitle = {Proceedings of the 25th annual meeting of Organization for Human Brain Mapping},
pages = {xx},
title = {{A simulation framework for validating surface-based cortical parcellation methods}},
year = {2019}
}
@inproceedings{Ivanov2019,
address = {Montreal, Quebec, Canada},
author = {Ivanov, Dimo and Haast, Roy A.M. and Desmond-Kennedy, Muriel and Poser, Benedikt A. and Uludag, Kamil},
booktitle = {Proceedings of the 27th annual meeting of International Society for Magnetic Resonance in Medicine},
pages = {xx},
title = {{Investigating the T1 of human venous blood a 7T in patients with diabetes, metabolic syndrome and healthy subjects}},
year = {2019}
}
@inproceedings{Haast2019a,
address = {London, ON, Canada},
author = {Haast, Roy A.M. and Ivanov, Dimo and DeKraker, Jordan and Kashyap, Sriranga and Janssens, Shanice C.E.W. and Poser, Benedikt A. and Khan, Ali R. and Uludag, Kamil},
booktitle = {Proceedings of the 17th annual meeting of Imaging Network Ontario},
pages = {xx},
title = {{Sub-millimeter blood flow mapping of cortical and hippocampal gray matter}},
year = {2019}
}
@inproceedings{Haast2019b,
address = {Montreal, Quebec, Canada},
author = {Haast, Roy A.M. and Ivanov, Dimo and DeKraker, Jordan and Kashyap, Sriranga and Janssens, Shanice C.E.W. and Poser, Benedikt A. and Khan, Ali R. and Uludag, Kamil},
booktitle = {Proceedings of the 27th annual meeting of International Society for Magnetic Resonance in Medicine},
pages = {xx},
title = {{Sub-millimeter blood flow mapping of cortical and hippocampal gray matter}},
year = {2019}
}
@PhdThesis{Haast:Doctoral,,
author = {Haast, Roy A. M.},
organization = {Department of Cognitive Neuroscience and Maastricht Centre for Systems Biology},
school = {Maastricht University, Netherlands},
title = {{Quantitative brain MRI at 7T in healthy subjects and in metabolic diseases}},
type = {Doctoral Dissertation},
year = {2018}
}
@mastersthesis{Haast:Doctoral,,
author = {Haast, Roy A. M.},
organization = {Department of Anatomy, Donders Centre for Brain, Cognition and Behaviour},
school = {Radboud University, Netherlands},
title = {{Sex Differences in Stroke}},
type = {Licentiate's },
year = {2012}
}